By Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell
The receptor proposal was once the most influential rules in 20th-century medication since it may possibly account for the hugely particular results of gear at the physique. This publication is the 1st to supply an ancient dialogue of its starting place, improvement, gradual popularity into pharmacology and next impression on sleek drugs. It additionally considers the social context that encouraged the drug receptor's development., creating a priceless contribution to the historical past and knowing of recent drugs.
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Extra info for A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History)
109 Ehrlich had friendships with many of his scientific opponents, but when it came to defending his theory, he launched a massive campaign against any critic, not only openly, but also behind the scenes. Ehrlich complained about seemingly disparaging remarks in the secondary literature. 110 Ehrlich sorted his colleagues into friends and enemies of his theory. 111 Again, Ehrlich related the remark to ‘the theory’, which occupied him more and more in the years after 1897. Comments made by Ehrlich’s critics give us further insight into the obsessive nature of his involvement in the receptor concept in this period.
He achieved his aims without any deeper insights into the exact way in which substances bind to cells, which explains why there was no discussion of the side-chains in the years after the publication of Ehrlich’s habilitation thesis. 43 And in 1898, when, together with a colleague, he published the results of his research on the blood cells, he pointed out the importance of clinical examination. 45 Ehrlich was mostly devoted to laboratory work, but this made sense for him only in connection with practical medicine: he tried to improve diagnostic techniques and tools to make them usable even for the untrained physician walking the wards.
Frerichs, whose efforts were based very much on contemporary experimental physiology, wanted to integrate laboratory research and laboratory diagnostics into clinical work on the wards. He supported Ehrlich’s staining experiments30 because he too combined his clinical work with his work at the laboratory bench in subsequent years. Ehrlich examined tissue specimens from the postmortem room to gain knowledge about the causes of patients’ deaths, and staining methods helped to explain the pathological functions of the morphological structures.
A Short History of the Drug Receptor Concept (Science, Technology and Medicine in Modern History) by Andreas-Holger Maehle, Cay-Rüdiger Prüll, Robert Francis Halliwell